CHICAGO -- One in 12 patients with incident hypertension screened positive for primary aldosteronism, suggesting expanded screening may boost detection, according to a real-world cohort study.
Among 2.5 million adults with incident hypertension, only 18,787 (0.76%) were screened for primary aldosteronism. Of the 9,414 individuals in this group who had available biochemical data, 819 (8.7%) screened positive for primary aldosteronism, reported Diana Grace Varghese, MD, of the University of Maryland in Rockville.
"Only 0.76% of eligible adults with incident hypertension were screened, so expanding screening may meaningfully improve primary aldosteronism detection," Varghese said at ENDO 2026, the annual meeting of the Endocrine Society. "An 8.7% positive rate in real-world screening is a meaningful yield."
"We all know primary aldosteronism is a common but underdiagnosed cause of hypertension," she added.
All individuals with hypertension should be screened for primary aldosteronism, according to Endocrine Society guidelines.
