June 08, 2026
7 min read
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NEW ORLEANS —A once-weekly combination therapy of cagrilintide and semaglutide reduced HbA1c and body weight across a wide range of adults with type 2 diabetes, according to data from three phase 3 trials. CagriSema (Novo Nordisk) is a combination drug consisting of the long-acting amylin receptor agonist cagrilintide and the GLP-1 receptor agonist semaglutide (Ozempic/Wegovy). During
June 08, 2026
7 min read
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GLP-1, Amylin Analog Combo Cuts Blood Sugar, Weight in Diabetes Trials

Once-Weekly CagriSema (Amylin-Semaglutide) Combination Injection More Effective than Standalone Medications

Novo Nordisk's CagriSema 2.4 mg / 2.4 mg demonstrated significant reduction in HbA1c and weight across multiple studies in the REIMAGINE program presented at ADA 2026

People with type 2 diabetes who were increased to semaglutide 2 mg were as likely to achieve an HbA1c less than 7% and more likely to achieve greater than 5% weight loss than those who were switched to tirzepatide, in real-world data

Novo Nordisk Highlights Positive Weight-Loss Data Across Multiple Programs - Novo Nordisk (NYSE:NVO)

ERA Congress: Semaglutide linked to better quality of life in diabetes and kidney disease, FLOW trial shows

Head-to-head Study Validates the Clinical Advantage of New-generation Biased GLP-1: Ecnoglutide Delivers 35% Greater Weight Loss than Semaglutide

Novo Nordisk's investigational zenagamtide shows significant A1C reductions with up to 14.6% weight loss in adults with type 2 diabetes—presented at ADA 2026

Zydus Semaglutide approval: Delhi HC directs CDSCO to decide on patient safety concerns

Novo Nordisk CEO Hints Semaglutide Could Be More Than Weight-Loss Drug - Novo Nordisk (NYSE:NVO)

Phase III trials back CagriSema in different type 2 diabetes populations

Once-Weekly CagriSema (Amylin-Semaglutide) Combination Injection More Effective than Standalone Medications

Novo Nordisk's CagriSema 2.4 mg / 2.4 mg demonstrated significant reduction in HbA1c and weight across multiple studies in the…

People with type 2 diabetes who were increased to semaglutide 2 mg were as likely to achieve an HbA1c less than 7% and more…

Once-weekly injectable semaglutide 2.4 mg was linked to reductions in body weight and improvements in multiple cardiometabolic…

Phase 3 trial results showed the once-weekly Cagrilintide monotherapy injection helped patients reduce their weight by 11.8% on…