The first weekend of June brings a well-rounded MLB slate to our screens. With about 100 or so games to go in this regular season, clubs are starting to solidify themselves. A cool mix of division rivalries and interleague mashups dot the next three days — led by a special telecast beneath the white frieze.Derek Jeter, Alex Rodriguez and David Ortiz take the broadcast booth as the New York Yankees welcome the Boston Red Sox on Saturday night. Their presence should add something to the ever-entertaining antagonism, and perhaps summon spirits from decades prior.Elsewhere, we get to see tough tests for upstarts like the Chicago White Sox and Pittsburgh Pirates, while the Seattle Mariners try to keep grooving into summer.Here’s what to check for from Friday through Sunday. May we all protect our heads and use our challenges wisely this weekend.All times are ET.MLB weekend watch guideGameTime (ET)TVStreamWhite Sox at Phillies6:40 p.m.,FridayMLB.TV (national)Chicago SN, NBCSP (local)Fubo (Watch Now)Rays at Marlins7:10 p.m., FridayMLB.TV (national)Rays.TV, Marlins.TV (local)Fubo (Watch Now)Mariners at Tigers1:10 p.m., SaturdayMLB.TV (national)Mariners.TV,Detroit SN (local)Fubo (Watch Now)Pirates at Braves4:10 p.m., SaturdayMLB.TV (national)SN Pittsburgh, BravesVision (local)Fubo (Watch Now)Red Sox at Yankees*7:35 p.m., SaturdayFoxFubo (Watch Now)Reds at Cardinals2:15 p.m., SundayMLB.TV (national)Reds.TV,Cardinals.TV (local)Fubo (Watch Now)Brewers at Rockies3:10 p.m.,SundayMLB.TV (national)Brewers.TV,Rockies.TV (local)Fubo (Watch Now)Giants at Cubs8:30 p.m., SundayNBCPeacock*Depending on local marketFox and NBC are free over the air. Fox is also available with a Fox One subscription.The headlinerBoston Red Sox at New York Yankees, 7:35 p.m. SaturdayThe three players who perhaps best defined this feud in the 2000s are calling Saturday’s primetime spot, with play-by-play voice Kevin Burkhardt anchoring the collective.Jeter batted .291 in 283 career games against the Red Sox, a drop-off from his .310 lifetime mark. But he famously took Pedro Martínez over the Green Monster in Game 3 of the 2003 ALCS, and 2004’s 12th-inning diving catch into the stands also came at Boston’s expense.Rodriguez was nearly traded to the Red Sox during the 2003 offseason, but the MLB players’ union rejected his proposed contract restructure. A-Rod ultimately linked up with Jeter in pinstripes — and joined this rivalry’s eternal lore when he fought Boston backstop Jason Varitek.Ortiz, meanwhile, crushed 52 regular-season home runs against the Yankees as a member of the Red Sox. The Boston faithful will forever remember his extra-inning walk-off home run in the 2004 ALCS, which spurred the Sox’s series comeback from a 3-0 deficit.There’s much to watch for with the current iterations of these teams, too. Heading into the series, New York has the best run differential in the American League. The Yankees also lead the AL in ERA and the majors in homers. Aaron Judge is sidelined due to a rib injury, but fellow basher Ben Rice ranks second in MLB in both slugging percentage and OPS. Boston is at the bottom of its division, though a series win in enemy territory could always inspire a midseason turnaround.Saturday’s probable pitchers are southpaw Ranger Suarez (2–3, 3.38 ERA) for the visitors and right-hander Will Warren (7–1, 3.22 ERA) for the hosts.The surprise teamsChicago White Sox at Philadelphia Phillies, 6:40 p.m. FridayThe previous three years of White Sox baseball have been a spiral of sadness: 61-101 in 2023, 41-121 in 2024 and 60-102 last season. Yet Chicago enters this weekend’s tangle at 33-29, with seven wins in its past 10 tries. As of Thursday, the South Siders are third in the AL in runs scored. Colson Montgomery and Miguel Vargas have 15 homers apiece from the left side of the infield. Get well soon, Munetaka Murakami.Surprise meets stardom in Philly. Kyle Schwarber has an MLB-best 23 long balls in 59 games. He’s on pace for 61 home runs, per FanGraphs. Bryce Harper, Trea Turner and the formidable Phillies are a tough test for Chicago probable Anthony Kay (5-1, 3.77 ERA).Tampa Bay Rays at Miami Marlins, 7:10 p.m. FridayTampa Bay boasts the best record in the AL after Thursday, even with a 2-8 slump across its last 10 games. The team is 28th in projected payroll, per FanGraphs, and it played below .500 in each of the last two seasons. Baseball is … weird.Junior Caminero (14 HRs), Yandy Díaz (.313 average) and Jonathan Aranda (43 RBIs) lead a fun offense into this Sunshine State series. Miami’s Otto Lopez is MLB’s current batting leader at .336.The hot teamsSeattle Mariners at Detroit Tigers, 1:10 p.m. SaturdayThe Mariners were 23-27 after May 19. They arrive in Detroit at 33-30 amid an inspired 10-3 run. Across its last 12 contests, Seattle has mashed an MLB-best 24 home runs. Julio Rodríguez has five of them. No Cal Raleigh, no problem — though the power-bat catcher is set to begin a rehab assignment for his oblique injury this weekend. Both ends are hot, too, as the M’s top all AL teams with a 2.72 ERA in that 12-game span.The banged-up Tigers are struggling at 25-38, but they did just sweep the AL-leading Rays.Pittsburgh Pirates at Atlanta Braves, 4:10 p.m. SaturdayCould this be the breakthrough year for these suddenly competent Buccos? Pittsburgh hasn’t put together a winning season since 2018’s modest 82-79 finish, and it hasn’t won a playoff game since the 2013 campaign. Oneil Cruz, Spencer Horwitz and Bryan Reynolds are all on a tear right now. The Pirates are 10-5 since getting walked off in St. Louis on May 19.Atlanta has been on a season-long heater, of course. Ronald Acuña and Matt Olson anchor baseball’s winningest team through 63 outings.The crowded NL CentralThrough Thursday, four of the six divisions have either one or two members above .500. The NL West looks comparatively loaded with three winning teams. And then there’s the NL Central, where all five teams are in the black right now. While the Pirates sojourn to the ATL, here’s what the rest of the division is up to:Cincinnati Reds at St. Louis Cardinals, 2:15 p.m. SundayTarps Off in St. Louis. There’s a real aesthetic joy to watching two predominantly red sides coming together. Their last meeting on May 23 was a 7-6 extra-inning banger — Cincinnati outfielder Blake Dunn had a game-saving sliding snag in the top of the 11th, and then he walked it off in the bottom half of the frame.Milwaukee Brewers at Colorado Rockies, 3:10 p.m. SundayMilwaukee averaged more than five runs per game through its first 60 contests. Christian Yelich, Jackson Chourio and the division-leading Brew Crew should put on a show in the thin air at Coors Field. If Colorado pulls off the upset, well, we get to see its glorious purple fur coat in action.San Francisco Giants at Chicago Cubs, 8:30 p.m. SundayThe halt-and-go Cubs need to establish some rhythm as they round into June. They notched two separate stretches of 10 straight Ws through May 8. Then they lost 10 in a row from May 16-26, and they haven’t won any of their last eight series. “Sunday Night Baseball” lands within the Friendly Confines to close out this weekend. Slumping Alex Bregman and his crew could use a get-right game before a national audience. Hey Chicago, what do you say?Streaming links in this article are provided by partners of The Athletic. Restrictions may apply. The Athletic maintains full editorial independence. Partners have no control over or input into the reporting or editing process, and do not review stories before publication.