Bolivia's defence and education ministers resigned on Tuesday after weeks of protests demanding President Rodrigo Paz step down, authorities said.
The departures are the latest escalation in a deepening political crisis that has paralysed major cities and threatened Paz's government.
Workers, farmers, miners, transport workers and teachers are demanding measures to ease the country's worst economic crisis in four decades.
Paz, who was backed by US President Donald Trump, has warned that Bolivia is at a "breaking point."
The government has refused to rule out declaring a state of emergency and using the military to control the demonstrations.
