Sabrina Brier is known to many as the "Oh!" lady, but over 1.2 million followers on Instagram and TikTok know she's much more than that. Brier's surprised/annoyed reaction — deployed in one of her riotous social media sketches — certainly captured an emotion hard to put to words, making it instantly meme-able. But all of her videos mine complicated female friendship for laughs, exposing truth bombs about ego, competitiveness, and insecurity in the process. "If I ever take anything directly from my friend's life, I ask for permission," Brier, 31, tells Mashable. "But, the other day, I posted one very loosely inspired by a friend's situation. She immediately commented on the video, 'Ummmm.'" After graduating from Smith College, Brier ground her way to social stardom, working as a writer's assistant for various shows before honing her comedy on Instagram during the pandemic. Her observant sketches of self-involved nightmare people endeared her to millions, securing her several brand deals and guest spots on shows such as Abbott Elementary.

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Brier's distinct comedy style is inspired by someone close to home, she admits. "My sister and I have a very comedic relationship! Sometimes when I'm trying out a new concept or character, in my head, I'm thinking, What would make her laugh? Those ones often turn out to be the funniest."From YouTubers and TikTok stars to streamers and podcasters, Mashable talks to creators about how they built their platforms, the gear they swear by, and the trends they see coming next. Read more of our creator coverage or see more of this year’s Mashable 101 to discover the internet's most exciting voices.