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The gastrointestinal surgeon’s tenure was marked by mass layoffs, persistent churn among senior leaders and policy fights.

A confluence of events ultimately led to the departure of FDA Commissioner Marty Makary. | Evan Vucci/AP

Marty Makary’s nine lives atop his agency are over.

The embattled Food and Drug Administration commissioner is resigning from his role Tuesday after 13 months leading the federal agency, according to an administration official granted anonymity to discuss the development.