New guidelines recommend doctors tackle Crohn's disease head-on, calling for the use of cutting-edge drugs as early as possible to quell the autoimmune GI disorder as quickly as possible.
The updated American Gastroenterological Association guidelines reject a "step-up" approach in which people get more advanced drugs only after they've tried cheaper, less effective medications like steroids or immunomodulating drugs like thiopurines.
Instead, doctors should go straight to monoclonal antibody drugs that target different factors that promote Crohn's disease, 2025 guidelines published in the journal Gastroenterology state.
"The science in Crohn's disease is moving quickly, and our goal was to translate that evidence into clear, meaningful recommendations for front-line clinicians," guideline author Dr. Siddharth Singh, a gastroenterologist with the Mayo Clinic in Phoenix, Arizona, said in a news release.
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