1 of 5 | Green Bay Packers running back Josh Jacobs (R) is the No. 2 player in my Week 6 fantasy football rankings. File Photo by Tannen Maury/UPI | License Photo
MIAMI, Oct. 9 (UPI) -- Saquon Barkley and Josh Jacobs lead my Top-50 fantasy football running back rankings for Week 6 of the 2025 season.
Jonathan Taylor, Bijan Robinson and Jahmyr Gibbs join Barkley and Jacobs inside my Top 5. Kyren Williams, Christian McCaffrey, De'Von Achane, Ashton Jeanty and James Cook are my other Top-10 options.
My Top-50 wide receiver rankings for Week 6 can be found here. My waiver-wire and free agent targets for Week 6 are available here.
All of my positional rankings will be updated until Week 6 kickoffs. Players also will be moved out of or adjusted within the rankings based on injuries. Omarion Hampton, who is ruled out, should be removed from starting lineups.
