Two potential NFL contenders have lost their starting quarterbacks due to injury. One seems better positioned to survive their top quarterback's absence than the other.

That would be the San Francisco 49ers, who earned a victory over the New Orleans Saints with backup quarterback Mac Jones leading the charge. Jones put together a strong showing in his first start with the 49ers which should quell any concerns about the team staying afloat without Brock Purdy.

Meanwhile, the Cincinnati Bengals lost quarterback Joe Burrow to an injury during their Week 2 game against the Jacksonville Jaguars. Jake Browning was able to guide the team to a come-from-behind victory, but with Burrow facing a long-term absence, the Bengals' outlook may not be as rosy as that of the 49ers.

Here are some of the most notable overreactions from Week 2 of the 2025 NFL season:

The Bengals may have earned a win over the Jacksonville Jaguars in NFL Week 2, but it came at a cost. Cincinnati lost Joe Burrow to a toe injury in the first half of their victory, and he did not return to action.