Israel has launched a deadly attack on Hamas leadership in Qatar, in an assault that threatens to plunge the region into a wider conflict.

Israel media, citing a senior Israeli official, said the attack was aimed at top Hamas leaders including Khalil al-Hayya, its Gaza chief.

Al-Jazeera reported that Hamas negotiators had been hit in Doha, quoting senior Hamas official. An AFP journalist said the explosions had rocked a Hamas compound.

Doha immediately condemned the 'cowardly' attack, described as a 'flagrant violation to all international law'.

An Israeli official said the United States had been notified before the strike, according to Reuters.