An explosion has rocked Manhattan's Upper East Side and sent plumes of smoke into the skies over New York City.

Around 100 firefighters and first responders were called to 305 E 95th Street on Friday morning around 10am after a massive fire broke out in the prewar building.

The fire reportedly started on the roof of the apartment complex, according to CBS News.

'There was a loud boom just before the fire and smoke started,' X user, Jimmy Chen, who was nearby, wrote on the platform.

Helicopter video shows dozens of firefighters spraying water on top of the 59-unit building.