A doctor has issued an urgent plea after it was revealed a sperm donor used to conceive at least 67 children across Europe has passed on a rare cancer-causing mutation.

Around 23 of those conceived from the donor's sperm between 2008 and 2015 have been found to carry a variant in the TP53 gene which provides instructions for making tumour proteins.

And 10 of these children have already been diagnosed with cancers such as leukaemia and non-Hodgkin lymphoma.

The case was described by Dr Edwige Kasper, a biologist at Rouen University Hospital in France, as an 'abnormal dissemination of genetic disease'.

She urged The Guardian: 'We need to have a European limit on the number of births or families for a single donor.