Anthropic has cut false positives in its biology safety filters for Fable 5 by about 85 percent. Previously, nearly all biology-related queries got blocked and rerouted to the less capable Opus 5. The restrictions stay in place for sensitive dual-use topics like virology and toxicology.

We’re making updates to Claude Fable 5’s biology safeguards in a way that substantially reduces fallbacks.

Anthropic cut Claude Fable 5's biology blocks by about 85% to curb false positives, while still barring dual-use work like virology and toxicology.