The number of adults with elevated LDL increased from 2.5 billion in 1990 to 4.6 billion in 2023, with 6% of all global deaths attributable to high LDL in 2023, according to study findings published in JAMA. Although age-standardized deaths and disability-adjusted life-years associated with elevated LDL decreased since 1990, the LDL burden shifted and now affects more middle-income countries,