Metformin may have been part of diabetes medicine for generations, but scientists are still uncovering new chapters in its story. The possibility that the brain participates in its glucose-lowering action is a reminder that the human body's metabolic system is deeply interconnected—and that even some of medicine's oldest tools can still teach researchers something unexpected.

For several decades now, one medication has been the primary drug used to treat type 2 diabetes, but research shows there's still a lot we can learn about how it works inside the…

Metformin may have been part of diabetes medicine for generations, but scientists are still uncovering new chapters in its story. The possibility that the brain participates in…