Identification of novel BRCA2 mutations in patients with multiple primary lung cancer

Although lung cancer is often linked to environmental exposures and acquired mutations, some patients develop multiple independent tumors, suggesting a potential role for inherited genetic susceptibility. While the contribution of germline pathogenic variants (GPVs) in several tumors is studied, their significance in lung cancer remains unknown. Now, researchers have explored the genetic basis of multiple primary lung cancers, offering insights into novel BRCA2 GPVs which could serve as targets for therapeutic strategies.

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