The FDA has approved sacituzumab govitecan-hziy as first-line therapy for adults with unresectable locally advanced or metastatic triple-negative breast cancer across PD-L1 status. Sacituzumab govitecan-hziy (Trodelvy, Gilead Sciences) — a TROP2-directed antibody-drug conjugate — received approval as a single agent for patients who are not eligible for PD-1 or PD-L1 inhibitors, and in

FDA grants Gilead two first-line approvals for Trodelvy in triple-negative breast cancer, broadening its reach beyond Datroway's narrower indication.

The game is on for TROP2 antibody-drug conjugates in first-line triple-negative breast cancer. | Less than a month after an approval for Daiichi Sankyo and AstraZeneca’s Datroway…