Major U.S. indices closed lower on Tuesday, with the Dow Jones Industrial Average declining 0.65% to 49,363.88.

Top analysts changed outlook on top names. Keybanc, Leerink, Wedbush, DA Davidson, Benchmark, Piper Sandler, Morgan Stanley, Evercore raised price targets.

Major U.S. indices closed lower on Tuesday, with the Dow Jones Industrial Average declining 0.65% to 49,363.88.