Maro Itoje is a replacement while Fraser Dingwall and Tommy Freeman form the midfield as England shake things up to face Wales.

Jamie George will lead England against Wales with Maro Itoje named among the replacements for Six Nations opener on Saturday

Plus: who will referee the Test and which England players missed out on the Six Nations squad

Maro Itoje is a replacement while Fraser Dingwall and Tommy Freeman form the midfield as England shake things up to face Wales.