The speech came as Iran and Europe negotiate over sanctions on the sidelines at the U.N. General Assembly. But Ayatollah Ali Khamenei said he opposed talks with the U.S., a key European demand.

Iran’s supreme leader on Tuesday ruled out direct talks with the United States over the nuclear program, likely ending a final bid to prevent the...

The speech came as Iran and Europe negotiate over sanctions on the sidelines at the U.N. General Assembly. But Ayatollah Ali Khamenei said he opposed talks with the U.S., a key…