Iran Supreme Leader Ayatollah Ali Khamenei Wednesday dismissed a U.S. proposal to halt Iranian uranium enrichment, appearing to reject a central U.S. demand in the nuclear program talks.

Trump and Steve Witkoff, who is leading the negotiations for the U.S., have repeatedly offered inconsistent public messages on a deal with Iran.

Iran's Supreme Leader Ayatollah Ali Khamenei said that abandoning uranium enrichment was "100%" against the country's interests.