Thursday Night Football in Week 2 of the 2026 NFL season features a marquee matchup between the Buffalo Bills and Detroit Lions, two teams with Super Bowl expec
Lions vs. Bills Prediction, Odds, Spread, Injuries, Trends for NFL Week 2
Buffalo is favored at home in this Week 2 matchup.
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The Buffalo Bills and quarterback Josh Allen are favored in Week 2. | IMAGN IMAGES via Reuters Connect
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Detroit Lions will travel on the road for a marquee matchup early in the 2026 NFL season.
Find out how to watch the Detroit Lions play the Buffalo Bills, with time, TV channel and streaming information.
