The San Francisco 49ers and Los Angeles Rams open the 2026 NFL season Thursday night. They will meet at the Melbourne Cricket Ground in Australia.A general overall view of the Melbourne Cricket Ground with images of San Francisco 49ers running back Christian McCaffrey (23) and Los Angeles Rams quarterback Matthew Stafford (9) on the facade. (IMAGN IMAGES via Reuters Connect)The 49ers have two big players returning from major injuries. Tight end George Kittle is active after recovering from a torn Achilles suffered in last January’s wild-card game. Defensive end Nick Bosa is also back after missing most of last season with a torn ACL. Defensive tackle Alfred Collins will miss the game with a knee injury.The Rams will be without star defensive tackle Aaron Donald. He did not travel with the team as he continues to work his way back into game shape after coming out of retirement. New pass-rusher Myles Garrett is expected to make his Rams debut.Also Read: Rams vs 49ers: Who is singing the national anthem today? Know about the Australian and US performersDepth chartHere's the projected depth charts for the San Francisco 49ers vs Los Angeles Rams Week 1 matchup:San Francisco 49ersOffense QB: Brock Purdy, Mac Jones, Kurtis RourkeRB: Christian McCaffrey, Kaelon Black, Jordan JamesFB: Kyle JuszczykWR (L/X): Mike Evans, Demarcus RobinsonWR (R/Z): Deebo Samuel Sr., Jordan WatkinsWR (S/slot): De’Zhaun Stribling, Jacob CowingTE: George Kittle, Jake Tonges, Luke FarrellLT: Trent Williams, Enrique Cruz Jr.LG: Carver Willis, Connor ColbyC: Jake Brendel, Jarrett PattersonRG: Dominick PuniRT: Colton McKivitz, Vederian LoweDefense LDE: Keion White, Khalid KareemLDT: Osa Odighizuwa, C.J. WestRDT: C.J. West / Gracen Halton (Alfred Collins out; James Thompson Jr. also in mix)RDE: Nick Bosa, Romello HeightWLB: Dre Greenlaw, Garret WallowMLB: Fred Warner, Tatum BethuneSLB: Jaden Dugger / Luke GiffordLCB: Renardo Green, Jack JonesRCB: Deommodore Lenoir, Ephesians PrysockNB: Upton StoutSS: Malik Mustapha, Marques Sigle, Ashtyn DavisFS: Ji’Ayir Brown, Siran NealSpecial Teams K: Eddy PiñeiroP: Corliss WaitmanLS: Jon WeeksPR/KR: Jacob Cowing / Deebo Samuel Sr. (and others)Los Angeles RamsOffense QB: Matthew Stafford, Stetson Bennett, Ty SimpsonRB: Kyren Williams, Blake Corum, Ronnie RiversWR (L/X): Davante Adams, Konata MumpfieldWR (R/Z): Puka Nacua, Tutu Atwell, CJ DanielsWR (S/slot): Jordan Whittington, Xavier SmithTE: Colby Parkinson, Tyler Higbee, Terrance Ferguson, Davis Allen, Max KlareLT: Alaric Jackson, David QuessenberryLG: Steve Avila, Bill Murray / Beaux LimmerC: Coleman Shelton, Dylan McMahonRG: Kevin Dotson, Beaux LimmerRT: Warren McClendon Jr.Defense (note: Aaron Donald out) DE: Braden Fiske (starting in place of Aaron Donald), Tyler DavisNT: Poona Ford, Ty HamiltonDT: Kobie Turner, Ty Hamilton / othersLOLB: Byron Young, Josaiah StewartLILB: Nate Landman, Shaun Dolac / Grant StuardRILB: Omar Speights, Grant StuardROLB: Myles Garrett, Desjuan JohnsonLCB: Jaylen Watson, Emmanuel Forbes Jr.RCB: Trent McDuffieNB: Quentin Lake, Josh WallaceSS: Kam Curl, Jaylen McColloughFS: Kamren Kinchens, Tanner IngleSpecial Teams K: Harrison MevisP: Ethan EvansLS: Joe CardonaPR/KR: Xavier Smith / Jordan Whittington (and others)