The role of H. pylori in colorectal cancer is controversial, despite a growing body of evidence supporting an association.Based on estimates from 43 studies, H. pylori exposure was associated with a 1.59-fold higher risk of colorectal cancer.In limited observational studies, eradication of H. pylori was associated with a reduced risk of colorectal cancer, but only after 10 years of follow-up.
Exposure to Helicobacter pylori, known for its role in gastric cancer, may also play a role in colorectal cancer (CRC), according to results from a risk-attribution modeling study.
Based on estimates from 43 studies, H. pylori exposure was associated with a 1.59-fold higher risk of CRC (95% CI 1.36-1.87), reported Shailja C. Shah, MD, MPH, of the University of California San Diego, and colleagues in eGastroenterology.
Under the pooled risk-attribution model based on estimates from the 43 studies, an estimated 22% (95% uncertainty interval [UI] 14.7-29.4) of global CRC cases were potentially related to H. pylori exposure. However, that proportion decreased to 11.9% (95% UI 0.7-22.8) when risk estimates were derived from 14 population-based and cohort studies.
In limited observational studies, eradication of H. pylori was associated with a reduced risk of CRC, but only after 10 years of follow-up.
