Every fantasy manager knows that schedule strength can greatly impact fantasy player performance. The more granular one can get in matchups, the better.My matchup points system uses various fantasy points and points allowed metrics as a base. Then, variables such as the likelihood of a team getting into a high-scoring game and pass-blocking/pass-rush strength are added. These combined grades are then placed on a curve and given a 1-100 score, with 1 being the least favorable and 100 being the most favorable.Keep in mind these grades are all based on fantasy-scoring relevance. For example, a defensive back who ranks high in yards per attempt (YPA) allowed but ranks low in PPR fantasy points per game (FPPG) allowed will be graded as a favorable matchup in this system.Now that we’ve covered the basics, let’s move on to the best and worst matchups for Week 1. The list below shows the entire scope of players with favorable and unfavorable matchups. I’ll highlight players from each positional list, beginning with quarterbacks.Metrics are via TruMedia/PFF, Stathead or NFL Next Gen Stats unless otherwise noted. Point references are in PPR unless otherwise noted.QuarterbacksFavorableJalen Hurts, PHI (100)Hurts has the highest season-long matchup points total at the quarterback position, and Week 1 is no exception. He'll face a Washington secondary that ranked 28th in vertical FPPG allowed last year and 27th in TE fantasy points allowed. Consider getting as many Eagles players into your lineup as possible this week.Jaxson Dart, NYG (86)Dart gets the Cowboys, who were by far the worst team in vertical FPPG allowed last year. Plus, Dallas' elite passing attack can turn this game into a scoreboard shootout; it’s a good week to have Dart in your lineups.Tyler Shough, NO (83)Shough ended last season with a six-game streak of 17+ points. Facing a banged-up Detroit secondary that will be without both of its starting safeties, Shough gets the type of matchup that could move the streak to seven.UnfavorablePatrick Mahomes, KC (15)There are myriad reasons to sit Mahomes. The Chiefs have made it clear they will run the ball a lot more this year, especially early on. Patrick Surtain (5 yards per target allowed last year) and Ja’Quan McMillian (5.9) are shutdown-caliber cornerbacks. There’s also the potential for injury-related rust and an outside shot that Mahomes is out for this Monday night matchup.Running backsFavorableOmarion Hampton and Keaton Mitchell, LAC (95)Mitchell is considered the Chargers' best breakaway threat, yet Hampton had a higher yards per carry total than Mitchell in my new breakaway rushing metric that measures how productive a ball carrier is when given breakaway-caliber blocking. That combined with Hampton facing a Cardinals rush defense that ranked 27th in fantasy points allowed on plus blocking plays (carries when the offense gives the rusher effective blocking) makes the Chargers' lead back a must-start in Week 1.