College football odds for Week 2: Texas favored against Ohio State in near toss-up

Arch Manning and Texas are small favorites against Ohio State in the biggest game on the Week 2 schedule. Tim Warner / Getty ImagesSept. 8, 2026 2:13 pm EDT Updated Ohio State at Texas is one of the most hyped game of the college football season. It’s Arch Manning getting another shot at the team that gave him fits in last season’s opener. It’s the Buckeyes taking their No. 1 ranking on the road to one of college football’s most renowned venues.Both programs are among the sport’s blue bloods and enter ranked inside the top five. That’s more than enough to hype up this matchup. The odds also say it should be very close.The Buckeyes are favored by 1.5 points. It doesn’t get much closer than that without being a true toss-up game.The total is at 48.5, which shows confidence in the defenses despite big name talent on both offenses. OSU won last year’s game 14-7, but the Buckeye defense has since lost a lot of talent to the NFL.

The other big-name program matchup of Week 2 features No. 11 Oklahoma at Michigan. The Wolverines are 1-0, but it doesn’t fully feel like it after the controversial final-second Hail Mary allowed them to escape against Western Michigan. Quarterback Bryce Underwood struggled mightily against the Broncos and now goes up against a Brent Venables defense. The Sooners are favored by 5.5 points on the road with a paltry 43.5-point total.Should Michigan have gotten an extra second?Chris VanniniThe Week 2 schedule also features a pair of nonconference rivalries with No. 23 Missouri at Kansas on Friday then Iowa State at No. 21 Iowa on Saturday. The Tigers are favored by 5.5 points at their classic rivals while the Hawkeyes are two-touchdown favorites against their in-state foes.In other games of note, No. 6 Oregon (-22.5) goes to Oklahoma State, No. 10 Texas A&M (-14.5) hosts Arizona State, No. 12 Alabama (-10.5) opens SEC play at Kentucky, No. 15 BYU (-7.5) hosts Arizona in a big early Big 12 clash and No. 18 Tennessee (-12.5) heads to Georgia Tech after the Yellow Jackets let one get away against Colorado in the season opener.Here’s a look at the odds for Week 2 for AP Top 25 teams, plus other noteworthy games on the schedule.College football odds: Week 2Thursday, Sept. 10Florida A&M at No. 7 Miami