In a cohort study of men with nonmetastatic prostate cancer, the highest level of post-diagnosis saturated fat consumption was associated with greater all-cause mortality compared with the lowest level.This increased risk of all-cause mortality was likely due to deaths from cardiovascular disease.There was no association between consumption of dietary fats and prostate cancer mortality.
Regularly eating certain dietary fats, including animal fats, was associated with greater all-cause mortality in men with nonmetastatic prostate cancer, a cohort study suggested.
Among nearly 4,900 men, the highest level of post-diagnosis saturated fat consumption was associated with greater all-cause mortality compared with the lowest level (HR 1.24, 95% CI 1.05-1.47), reported Lorelei Mucci, ScD, MPH, of the Harvard T.H. Chan School of Public Health in Boston, and colleagues.
As might be expected, death from cardiovascular disease was a likely reason for the increase in all-cause mortality (HR 1.42, 95% CI 1.02-1.98), they noted in JAMA Network Open.
In addition, animal fat, a major source of saturated fats, was positively associated with deaths from other cancers (HR 1.49, 95% CI 1.00-2.21). Notably, replacing 10% of calories from animal fats with plant-based fat sources (HR 0.84, 95% CI 0.76-0.93) and replacing 5% of calories from saturated fats with monounsaturated fats (HR 0.80, 95% CI 0.70-0.91) was associated with a decrease in all-cause mortality.
