Jump to contentAllNewsSportCultureLifestyleNovak Djokovic suffered his first opening-round exit at a Grand Slam tournament since 2006 after losing to Argentina's Mariano Navone at the US Open. The 24-time major champion lost 7-6 (5) 5-7 4-6 6-2 6-1 in a five-set match lasting four hours and 36 minutes while suffering from vomiting, severe cramping, and body pain. Djokovic admitted after the match that he carries a serious health issue and "despised every moment" on court, though he congratulated world number 49 Navone on the biggest win of his career. The defeat is the 39-year-old’s earliest exit at a major since his defeat by Paul Goldstein at the 2006 Australian Open. He had never lost in the first round at the U.S. Open.In the late match on Arthur Ashe Stadium, 46-year-old former champion Venus Williams squandered seven set points in the second set before losing 6-2 7-6 (6) to Sofia Kenin. In fullNovak Djokovic breaks down in tears after gruelling five-set US Open defeatMore bulletinsThank you for registeringPlease refresh the page or navigate to another page on the site to be automatically logged inPlease refresh your browser to be logged in