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The couple plans a Manhattan neuroscience and longevity center inspired by Ackman's daughter, who suffered a brain hemorrhage

Bill Ackman and his wife, Neri Oxman, are donating roughly $400 million in Pershing Square $SQ stock to fund a new Manhattan brain research center, with a second gift of similar or greater size to follow.

The couple announced the Ackman Oxman Institute, or AOI, on Wednesday, with Ackman writing in an X $TWTR post that his Pershing Square Foundation had donated 10 million shares of Pershing Square Inc. to anchor the venture. The shares were worth close to $400 million at Wednesday's closing price, according to Bloomberg. Ackman said a second donation of comparable or potentially greater value, not in the form of Pershing Square stock, would be announced later.

"Our goal is to build the world's greatest brain research, rehabilitation, recovery, human optimization, and longevity institute," Ackman wrote.