SynGenSys Introduces Expanded CHO.SET Synthetic Promoter Library for Enhanced Biomanufacturing
CHO.SET® 2.0 library of synthetic promoters provide tuneable expression of transgenes whilst maximising CHO cell productivity
CHO.SET® promoters enable higher protein titres, reduced costs and shorter development timelines
SynGenSys, a biotechnology company designing synthetic gene promoter systems to address critical bottlenecks in biopharma manufacturing and enhance cell and gene therapy development, today announced the introduction of CHO.SET® 2.0. The expanded library of novel and patentable synthetic promoters is designed to improve protein production in CHO (Chinese Hamster Ovary) cells.
The CHO.SET Library® was first introduced in 20241, and has since been expanded and optimised, reflecting SynGenSys’ continued commitment to addressing critical biomanufacturing bottlenecks. Current market vectors rely heavily on natural promoters such as CMV and SV40E, which have restricted transcriptional activity and are therefore insufficient for generating the high productivities required for modern commercial biotechnology applications. Developed de novo using the Company’s proprietary transcriptional analysis and sequence engineering platform, CHO.SET® synthetic promoters combine advanced computational design with empirical validation to deliver a highly diverse promoter library applicable across a wide range of CHO expression systems and biomanufacturing requirements.
