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Gilead Sciences’ HIV prevention business reached a milestone, exceeding $1 billion in quarterly sales for the first time. | Gilead’s HIV prevention business reached a milestone, exceeding $1 billion in quarterly sales for the first time, as highlighted by CEO Daniel O’Day. But one group of analysts is raising doubts about the long-term growth of Yeztugo, the company’s much-touted long-acting PrEP option.
Gilead's Yeztugo injection hit $232M in Q2 2026 with 70%+ persistence, leading the PrEP switch market in four quarters. The parallel weekly oral formulation—tacitly admitting 80-85% prefer oral convenience—signals Yeztugo durability risks and a capped injectable TAM versus consensus.
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