This handout picture provided by the Vatican Media shows Pope Leo XIV holding his weekly general audience at Saint Peter's Basilica in Vatican City, Wednesday. EPA-Yonhap

VATICAN CITY — Pope Leo XIV will make his first trip to Latin America as pontiff in November, returning to a region where he spent much of his ministry, with visits to Uruguay, Argentina and Peru, the Vatican announced Wednesday.

The Nov. 6-17 trip will include stops in Montevideo, Paysandu and Florida in Uruguay; Buenos Aires, Córdoba and Lujan in Argentina; and Lima, Chiclayo, Cusco and Pucallpa in Peru.

The visit is especially significant because of Leo’s longstanding ties to Peru. The first U.S.-born pope spent decades there as a missionary and church leader and served as bishop of Chiclayo from 2015 to 2023. He also holds Peruvian citizenship.

His return to Chiclayo, the diocese he led before his election, is expected to be one of the key moments of the trip.