Six months after Savannah Guthrie’s mother, Nancy Guthrie, disappeared from her home in Tucson, Arizona, NBC “Today” show anchor Savannah Guthrie said the family is “begging for help” in a new Instagram post on Saturday morning.

“We have lived every moment, every breath, and every heartbeat in agony and despair ever since,” Savannah Guthrie wrote in the caption of a photo of Nancy Guthrie smiling at the camera.

“Our hearts are in ruins,” Savannah Guthrie said, adding that she and her siblings “spend every waking moment thinking of her, longing for her, looking for” their mother.

Nancy Guthrie, 84, did not have her phone or essential medication when she disappeared from her home in the early morning hours of February 1.

Investigators have chased leads that appeared to offer hope, including video evidence and thousands of tips, but each day has ended without the result her family desperately wants: bringing her home.