Mayo Clinic is a nonprofit academic medical center headquartered in Rochester, Minnesota, with additional campuses in Arizona and Florida and a regional health system spanning three Upper Midwest states. The organization employed nearly 85,000 people in 2025 and posted $473 million in operating income. Mayo committed $9 billion in capital investment through its “Bold. Forward. Unbound.” expansion. Independent rankings have named it Newsweek’s No. 1 hospital in the world for the eighth consecutive year.
That scale extends to artificial intelligence. Mayo describes more than 200 AI projects underway across stages of maturity, from early feasibility work to full clinical deployment.
In 2025, Mayo integrated 22 AI-enabled Mayo Clinic Platform solutions into clinical practice and closed nearly 200 new AI, biopharma, and diagnostics agreements.
Since launching the Mayo Clinic Platform in 2019, it has assembled a research data infrastructure spanning more than 15 million patient records and billions of radiology images, lab results, and clinical notes.
This article examines two AI use cases that show how Mayo applies that data and clinical expertise inside its own operations.
