Fresh US strikes triggered air defenses in Tehran on Wednesday after President Donald Trump warned he was "not finished" with a war with Iran that has already cost his nation $37.5 billion.After the foes' fighting over the strategic Strait of Hormuz led to the collapse of a preliminary deal, the Middle East war has expanded to include the region's other key chokepoint for global oil supplies.

Still, top US diplomat Marco Rubio reiterated Washington's statement that it is willing to use diplomacy to find an agreement with Tehran.

"The problem we are currently facing is that they are not taking the negotiations seriously," Rubio said at a Southeast Asia ministers' meeting in Manila.

Iranian foreign ministry spokesman Esmaeil Baqaei has said that diplomatic exchanges with Washington through mediators were continuing.

The latest round of Middle East attacks included US forces hitting targets such as "military logistics infrastructure", while Iranian state media reported strikes around the country, including Bushehr, which hosts a nuclear power plant .