At least five people are unaccounted for in southeastern Missouri, officials say, amid historic flooding in the region that has prompted multiple water rescues Friday.

The five were camping along the Black River in Reynolds County, county Emergency Coordinator Steve Chitwood told CNN. CNN has reached out to authorities for more information.

Flash flooding inundated areas around the river Friday morning. Around 10 people had to be rescued from the rooftop of the Black River Lodge, Chitwood said. The Black River Bridge in Centerville, Missouri, has also been closed and water is over roadways in other areas.

The National Weather Service issued a flash flood emergency — the highest level of flood warning — for more than 4,000 people in parts of Reynolds and Iron counties in southeastern Missouri early Friday morning.

The torrential rain that prompted the warning has ended, but the emergency remains in effect for much of Friday afternoon due to lingering flooding issues. Additional rain is possible in the area late Friday and over the weekend.