Current standings: England sit top of Group L on four points heading into the final round of fixtures.
Ghana are level on points and trail by only one goal on goal difference, followed by Croatia in third and Panama in fourth.
Head-to-head: England and Ghana played out a goalless draw on Tuesday evening in Boston.
With their head-to-head record level, goal difference becomes the next tie-breaker to separate the two sides.
If England win: Victory over Panama on Saturday would leave the Three Lions in a commanding position to finish top of the group.
