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Uruguay bowed out of the World Cup as goalkeeper Fernando Muslera's howler gifted Spain a 1-0 win in Guadalajara to secure top spot in Group H.
Alex Baena's weak shot slipped through Muslera's grasp for the only goal as Spain avoided a last 32 showdown against Argentina.
The European champions will instead face Austria or Algeria next in Los Angeles on Thursday.
Uruguay's defeat allowed debutants Cape Verde to secure second place and a meeting with Lionel Messi and the defending champions thanks to a 0-0 draw against Saudi Arabia.
