June 24, 2026
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The FDA has approved the first and only cyclin-dependent kinase 4/6 inhibitor for patients with HR-positive metastatic breast cancer, regardless of HER2 status. Palbociclib (Ibrance, Pfizer) was approved in combination with trastuzumab (Herceptin, Genentech), with or without pertuzumab (Perjeta, Genetech), and endocrine therapy as maintenance treatment for adults with HR-positive,
June 24, 2026
1 min read
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FDA Approves CDK4/6 Inhibitor for HER2-Positive Breast Cancer

FDA Approves Pfizer’s IBRANCE Regimen for HR+, HER2+ Metastatic Breast Cancer Frontline Maintenance

Pfizer scores 1st expansion in 7 years for breast cancer blockbuster Ibrance

Gilead’s Trodelvy nabs broad FDA approval in front-line TNBC, fueling TROP2 ADC market war

First-Line Options in HER2-Positive Metastatic Breast Cancer

FDA backs Gilead’s Trodelvy for first-line, triple-negative breast cancer

PATINA trial paved the way for palbociclib-based frontline maintenance regimen

FDA Approves Pfizer’s IBRANCE Regimen for HR+, HER2+ Metastatic Breast Cancer Frontline Maintenance

It’s been seven years since Pfizer scored an expansion for its breast cancer blockbuster Ibrance, and during that time, the drug…

The FDA approved datopotamab deruxtecan-dlnk as the first TROP2-directed antibody drug conjugate for first-line treatment of…

How data from HER2CLIMB-05 and PATINA are influencing treatment decisions

New trastuzumab deruxtecan indications cover neoadjuvant and adjuvant treatment