Secretary of State Marco Rubio announced sanctions Tuesday against five Cuban state entities. File Photo by Bonnie Cash/UPI | License Photo

June 24 (UPI) -- The United States has sanctioned five Cuban state companies and the wife of Raul Castro's son, as the Trump administration continues to apply economic pressure on the Caribbean nation.

Three of the companies blacklisted by the State Department on Tuesday are associated with Grupo de Administracion Empresarial, which the United States initially sanctioned during the first Trump administration on accusations of being a Cuban military-controlled umbrella enterprise with interests sprawling throughout the island nation's economy.

The two other entities hit are accused of operating in Cuba's mining sector with foreign investment from Australia as well as working in collaboration with Russia.

Annalie Lilliam Rueda Cadero was sanctioned for being the wife of Alejandro Castro Espin, the son of Raul Castro, Cuba's former head of state. Alejandro Castro was sanctioned by the Trump administration earlier this month.