Federal Reserve Board Chairman Alan Greenspan testifies on Capitol Hill, Nov. 3, 2005, in Washington. AP-Yonhap

Alan Greenspan, hailed as the greatest Federal Reserve chairman when he retired in 2006 but derided for a severe financial crisis that followed barely two years later, died on Monday aged 100, his wife said.

Greenspan, who exerted a powerful influence on the U.S. economy during his tenure at the helm of the Fed from August 1987 to January 2006, died at his home from complications of Parkinson's Disease, Andrea Mitchell said in a statement.

"He was a giant of a man who helped shape the U.S. economy for decades under presidents of both parties, but was always honest in acknowledging his mistakes," Mitchell said.

"He will be remembered for his brilliance and his kindness. Being his life partner was the joy of my life," she added.