While the New York Giants eye a renaissance under head coach John Harbaugh, it's appropriate to look back at some of the most impactful and memorable players who have worn the uniform over the last 20 years.A new era is underway, but there is plenty to remember and appreciate in those who preceded it.Pro Football Focus has it covered. The sports analytics company used its grading system to determine the 12 best offensive and 12 best defensive players who have represented Big Blue at any time since 2006.The offense consists of quarterback Eli Manning, running back Ahmad Bradshaw, wide receivers Odell Beckham Jr., Hakeem Nicks, and Victor Cruz (slot), tight ends Kevin Boss and Jeremy Shockey, left tackle Andrew Thomas, left guard Rich Seubert, center Shaun O'Hara, right guard Chris Snee, and right tackle Kareem McKenzie.The defense is made up of interior defensive linemen Dexter Lawrence II and Damon "Snacks" Harrison, edge rushers Justin Tuck and Jason Pierre-Paul, linebackers Bobby Okereke, Blake Martinez and Devon Kennard, cornerbacks Corey Webster, Janoris Jenkins and Dominique Rodgers-Cromartie (slot), and safeties Kenny Phillips and Landon Collins.There is plenty to dissect on this loaded roster, with legacy, consistency and notable omissions drawing focus.The OffenseOct 13, 2024; East Rutherford, New Jersey, USA; New York Giants former quarterback Eli Manning on the field before a game against the Cincinnati Bengals at MetLife Stadium. | Brad Penner-Imagn ImagesChampions, unsurprisingly, define this unit, with two-time Super Bowl MVP Eli Manning leading the way. Hakeem Nicks, Victor Cruz, and Ahmad Bradshaw all made huge plays on the big stage as well.Not to be forgotten, offensive linemen Chris Snee and Kareem McKenzie played an integral role in both title runs. No. 10 might not have reached hero status without them or the other blockers in this group. Of course, one did not need to win a ring with New York to make a lasting impression.Odell Beckham Jr. recorded 1,300-plus receiving yards and 10 touchdowns or more in each of his first three seasons with the Giants, earning himself Rookie of the Year honors and back-to-back Second-Team All-Pro selections.Andrew Thomas, who remains an indispensable member of the trenches, joins the returning Beckham as the only two active members of the Giants on this PFF squad.May 21, 2026; East Rutherford, NJ, USA; New York Giants offensive tackle Andrew Thomas (78) speaks at a press conference during organized team activities at Quest Diagnostics Training Center. | John Jones-Imagn ImagesThe big omission is running Saquon Barkley, which Jahnke attributes to Bradshaw's receiving efficiency and superior blocking. Championship brilliance also helps the latter's case, as the former was forced to compete on a severely limited roster for much of his tenure with the G-Men.Despite Barkley's absence from this All-PFF Team, there is little one can reasonably nitpick on the offense. Most of these men earned their slots by contributing to the most celebrated and improbable period in Giants history.The defensive choices arguably leave more room for debate, given the more recent turnover on that side of the ball.The DefenseFormer New York Giant Justin Tuck watches teammate Eli Manning (not pictured) have his jersey retired during the Ring of Honor ceremony at MetLife Stadium on Sunday, Sept. 26, 2021, in East Rutherford.