Vice President JD Vance on Thursday warned U.S. critics in Israel against "attacking the only powerful ally" left in the world, in an extraordinary rebuke after Washington and Tehran signed a deal to end the Middle East conflict.

Vance told members of the Israeli government criticizing the agreement to "wake up and smell the reality," amid growing tensions between Prime Minister Benjamin Netanyahu and President Donald Trump.

He warned them that "Donald J. Trump is the only head of state in the entire world who is sympathetic to the nation of Israel at this moment in time."

"If I was in the cabinet of the Israeli government, I might not be attacking the only powerful ally that I have anywhere left in the entire world," Vance told a briefing at the White House.

U.S. and Israel jointly launched the war on Iran on Feb. 28, but Trump has chastised Israel for continuing attacks on Lebanon that threatened to derail the deal with Tehran.