Caliway Unveils Latest OI25 Animal Study Data for CBL-514 in Combination with GLP-1R-Based Weight-Loss Therapies at ADA 2026, Demonstrating Dual Potential to Attenuate Post-Discontinuation Weight Regain and Improve Metabolic Health
PR Newswire
NEW TAIPEI CITY, June 11, 2026
Backed by International Authority — Caliway's latest preclinical data on its proprietary localized fat reduction candidate, CBL-514, in combination with GLP–1R–based weight–loss therapies, were presented at the American Diabetes Association 2026 Scientific Sessions (ADA 2026). The findings were delivered by Timothy Garvey, MD, an internationally renowned expert in obesity and metabolic medicine and a scientific advisor to Caliway, garnering significant interest from global experts and multinational pharmaceutical companies.Attenuation of Post–Discontinuation Weight Regain — The newly disclosed OI25 animal study confirmed that CBL–514 combined with GLP–1R–based therapies achieved superior weight loss compared to monotherapy. Following treatment cessation, weight regain in the monotherapy group was 2.7 times that observed in the CBL–514 combination group, underscoring the potential of combination therapy to mitigate post–discontinuation weight rebound.Improvements Across Multiple Metabolic Parameters — The data further demonstrated that adding CBL–514 to tirzepatide resulted in an additional 106.7% reduction in hepatic lipid content relative to tirzepatide alone, along with marked improvement in the HOMA–IR index of insulin resistance. These findings expand the scientific value of CBL–514 beyond localized fat reduction into the domains of weight management and metabolic health.NEW TAIPEI CITY, June 11, 2026 /PRNewswire/ -- Caliway Biopharmaceuticals (TWSE: 6919) announced on June 10 that the latest preclinical study data on its first–in–class, large–area localized fat reduction drug candidate, CBL–514, in combination with the GLP–1R–based weight–loss therapy tirzepatide, were presented at the American Diabetes Association 2026 Scientific Sessions (ADA 2026), one of the world's premier clinical medicine conferences.
