Data availabilityThe crystal structure of the FXR–linafexor complex bound to the second LXXLL peptide motif from SRC2 has been deposited in the PDB under PDB ID 9LQ3. Superposition of the linafexor-bound FXR complex with the tropifexor-bound structure can be found under PDB ID 7D42. The transcriptomics data were uploaded to the National Genomics Data Center (https://ngdc.cncb.ac.cn/gsa/; reference ID CRA038114). Source data are provided with this paper.ReferencesEvans, R. M. & Mangelsdorf, D. J. Nuclear receptors, RXR, and the Big Bang. Cell 157, 255–266 (2014).Article
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