Crownlands Releases Largest Open-Source Dataset of Living Patient Cells to Advance AI-Driven Research in Alzheimer’s and Neuroscience
Four million single cells from 200-plus donors capture human neuronal biology in tissue context, now accessible via the Chan Zuckerberg Initiative’s CZ CELLxGENE platform
Crownlands, Inc., a company scaling the collection of living human neurons to generate molecular data for AI-driven drug discovery and clinical trial modeling, today announced the public release of a large-scale single-cell dataset derived from olfactory neurons, marking the company’s launch and introducing a new resource for the neuroscience community. The de-identified dataset, comprising four million cells from more than 200 donors, is now freely accessible to the scientific community via the Chan Zuckerberg Initiative’s CZ CELLxGENE platform. It represents the largest single-cell dataset on the platform from living human donors and is intended to support target discovery, biomarker development, and translational research in Alzheimer’s disease (AD) and other neurodegenerative conditions.
Alzheimer’s disease remains one of the largest unmet needs in medicine, with persistently low clinical success rates. The field’s focus on a narrow set of targets reflects limited access to human disease biology. While longitudinal sampling of disease-specific tissue has driven mechanistic discovery in other areas, it has not been possible in neuroscience, where brain biopsy from living human donors is not viable at scale.
