The NLM Drug Interaction API is gone — here's what to use instead

The NLM Drug Interaction API Was Discontinued in 2024 — Here's How to Replace It

On January 2, 2024, the National Library of Medicine quietly killed its Drug-Drug Interaction API. No replacement. No migration path. Just a notice on the docs page and a broken endpoint for every app that depended on it.

If your code is calling rxnav.nlm.nih.gov/REST/interaction and getting nothing back, that's why. It's not a temporary outage. It's gone.

This post covers exactly what was discontinued, what's still alive, and how to build a working replacement.

What exactly was discontinued