Leucovorin prescriptions for autism up by over 2,000% in recent months

Prescribing rates for leucovorin among youth with autism was 24-fold higher in November 2025 compared with the average prescribing rate from January 2023 to January 2025, according to a research letter published in JAMA Network Open. Joshua “Yoshi” Rothman, MD, MS, a clinical assistant professor of pediatrics at the University of California, San Diego School of Medicine, told