In addition to coverage of related events and exhibits, the Gazette will publish a series of occasional features marking the 250th anniversary of the Declaration of Independence.

It took days for John Warren to find his missing older brother. When he did, his worst fears were confirmed: Joseph, a Colonial militia general and guiding light for Warren, had been killed in battle on Breeds Hill in June of 1775.

A grieving Warren initially reached for his gun, but cooler heads persuaded the young physician he’d be more valuable to the cause treating the wounded in Cambridge during the Siege of Boston, then in its early months.

Warren was part of a revolutionary generation that counted a number of Harvard graduates in its ranks. They played key roles in the birth of the nation and in defining its character in the years that followed.

In the ensuing years, Warren would pass through the upheaval of the Revolution, taking the accelerated lessons in medicine and innovation learned in battlefield surgery back to his Boston practice. The Harvard graduate became noted as a doctor and lecturer, skills would serve him as the primary founder of Harvard Medical School in 1782.