An American national on a repatriation flight has tested positive for hantavirus while another has mild symptoms after leaving a cruise ship hit by a deadly outbreak of the virus, the US health department has said.

Both passengers on the government charter plane are travelling in "biocontainment units out of an abundance of caution", the statement says.

Upon arrival, all 17 US citizens on the flight will be further screened at a medical facility in Nebraska.

They are among more than 90 passengers of the MV Hondius ship, now docked in Spain's Canary Islands, who are being repatriated. Officials say the risk of a major outbreak is very low.

Three passengers - a Dutch couple and a German woman - have died after travelling on the vessel. Two of them are confirmed to have had the virus.